Not a single course... but 18 individual holes?

l can not give you 18, but l will throw 3 your way. Number 17 at the TPC at Sawgrass is usually up there and very entertaining to watch. The 18th at Bay Hill is considered one of the toughest finishing holes in golf. And, most of the back nine at a Augusta, but Amen Corner is where a lot of the pros get into trouble with number 12 being my favorite. Tough question! So many good one is to choose from.

In 2008 the toughest holes were statistically :

1. 6th royal birkdale
2. 18th Oakland
3. 12th torrey pines
4. 18th sawgrass
5. 1st royal birkdale
6. 6th torrey pines
7. 7th torrey pines
8. 12th TPC southwind
9. 14th TPC sawgrass
10. 8th Oakland hills

Then you've got the usual 4th and 11th at Augusta, 17th at sawgrass, 4th at firestone, 9th at pebble beach, 3rd at doral.

The eighth at Pebble Beach
the 12th at Augusta
Pinehurst #2 5th
The 9th at Pebble Beach
Cypress Point 16th
Rivieras 18th
the 1st at Oakmont
18th at Doral
17th at Olympic Club
17th at Bay Hill
The 17th at Sawgrass when the wind is up//
After these there are just a ton that could be used to fill out the list

Here is the Top 18 on the 2008 PGA Tour. Ten of them were played in the last three majors, but u did not specify majors versus non-majors.

Here ya go:

1. #6 . Royal Birkdale - BRITISH. +0.764
2. #18 . Oakland Hills (South) - PGA . +0.661
3. #12 . Torrey Pines (South) - U.S. OPEN . +0.581
4. #18 . TPC Sawgrass - PLAYERS . +0.522
5. #1 . Royal Birkdale - BRITISH . +0.513
6. #6 . Torrey Pines (South) - U.S. OPEN . +0.504
7. #7 . Torrey Pines (South) - Buick Invite . +0.491
8. #12 . TPC Southwind - St. Jude . +0.450
9. #14 . TPC Sawgrass - PLAYERS . +0.447
10. #8 . Oakland Hills (South) - PGA . +0.446
11. #6 . PGA National (Champion) - Honda . +0.444
12. #11 . Royal Birkdale - BRITISH . +0.437
13. #7 . Oakland Hills (South) - PGA . +0.422
14. #10 . Royal Birkdale - BRITISH . +0.420
15. #16 . Innisbrook Resort (Copperhead) - PODS . +0.419
16. #17 . Quail Hollow - Wachovia . +0.418
T17. #3 . TPC Four Seasons - Byron Nelson . +0.396
T17. #9 . Oakland Hills (South) - PGA . +0.396

l think 17th at TPC Sawgrass is the hardest

the ones your trying to play!!

Royal Birkdale is not on the PGA Tour.

Number 8 at oakmont is a LONG par 3

I'd say Augusta, even though it is a major, they play it every year.